Similar lesions were not observed in the rat or mouse following acute, subchronic or chronic dietary exposure, and there was no other evidence in any other species tested to indicate a neurotoxicity potential. Name: Trinexapac-ethyl: Trinexapac-ethyl; 4- (Cyclopropyl-alpha-hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester; Ethyl 4-cyclopropyl (hydroxy)methylene-3,5-dioxocyclohexanecarboxylate This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. Therefore, apply trinexapac-ethyl in 20 to 30 gallons of water per acre. The literature also shows that reduction in lodging is relative to the straw strength of the variety. legal research should verify their results against an official edition of Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. A . Registration Review. EPA uses the term post-application to describe exposure to individuals that occur as a result of being in an environment that has been previously treated with a pesticide. It is not an official legal edition of the Federal Formula: C 16 H 24 O 5 Si; Molecular weight: 324.4443; . Other names: Trinexapac-ethyl, trimethylsilyl ether Permanent link for this species. Trinexapac-ethyl, TMS derivative. on electronic version on GPOs govinfo.gov. This action is not a major rule as defined by 5 U.S.C. In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). hbbd``b`Z$@`N{!:X "Dh,T&Fv B From non-dietary exposure. The President of the United States communicates information on holidays, commemorations, special observances, trade, and policy through Proclamations. on Trinexapac-ethyl is currently registered for uses that could result in short- and intermediate-term residential exposure, and the Agency has determined that it is appropriate to aggregate chronic exposure through food and water (considered to be a background exposure level) with adult post-application dermal exposure estimates for trinexapac-ethyl. The petition requested that 40 CFR part 180.662 be amended by establishing tolerances for residues of the herbicide trinexapac-ethyl, (4-(cyclopropyl-a-hydroxy-methylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester), and its primary metabolite CGA-179500 in or on sugarcane, cane at 1.5 parts per million (ppm) and sugarcane, molasses at 5.0 ppm. from 47 agencies. The reasons for these are explained in Unit IV.D. Garbacik, Chun-hui Ma, and C.W. clothing Rinse skin immediately with plenty of water for 15-20 minutes. Important Announcement. Trade name Tweak Yield and Quality Enhancer Other names: Trinexapac-ethyl 250 g/L EC, CHA 8830 Product Use: Improves the percent of thebaine in Poppies. Avoid contact with skin and eyes. should verify the contents of the documents against a final, official documents in the last year, 662 Last updated on July 5, 2022 All Rights Reserved. X. . Table 2.2.3, Tolerance Summary for Trinexapac-ethyl summarizes these differences on page 8 of the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed which is located in docket ID number EPA-HQ-OPP-2010-0524. Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. . documents in the last year, 474 It inhibits vertical shoot growth, while producing healthy, durable blades in turfgrass. Roanoke, VA 24016. III. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. Following chronic exposure, dose-related neuropathology of the brain was seen at 365/357 mg/kg/day in male and female dogs respectively. Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. In addition, this final rule does not impose any enforceable duty or contain any unfunded mandate as described under Title II of the Unfunded Mandates Reform Act of 1995 (UMRA) (Pub. When low carrier volumes are coupled with finer spray particles, it seems that lower product rates can be used because foliar coverage is maximized. While every effort has been made to ensure that Trinexapac-ethyl is approved for use on cereal crops such as barley, durum wheat, oats, rye, triticale and wheat as well as grassland, amenity turf and managed turf. That document referenced a summary of the petition prepared by Syngenta Crop Protection, LLC, the registrant, which is available in the docket, http://www.regulations.gov. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health There are no established or proposed Codex, Canadian, or Mexican MRLs for trinexapac-ethyl in or on any food or feed crops.Start Printed Page 12745. Quick Resources. To summarize this first year of work with plant growth regulators, we found a trend for one to two inch reductions in plant height when Palisade or Palisade plus Tilt were applied, but this only translated to increased grain yield at one site. Relevant information about this document from Regulations.gov provides additional context. Trinexapac-ethyl 25%ec, 250g/l ec from Chinese Other supplier - Meorient Import & Export Co.LTD on tradechina.com . To summarize our work, we found a trend for one to two inch reductions in plant height when Palisade or Palisade plus Tilt were applied, but this did not consistently translate to increased grain yield. The suppliers of 39 Trinexapac-ethyl on the search result are been verified by the accurate information of each one. In this Issue, Documents Molecular Formula CHO. Adequate enforcement methodology (Method GRM020.01A, which utilizes high performance liquid chromatography with triple-quadrupole mass spectrometry (LC-MS/MS)) is available to enforce the tolerance expression. Potentially affected entities may include, but are not limited to those engaged in the following activities: This listing is not intended to be exhaustive, but rather to provide a guide for readers regarding entities likely to be affected by this action. on documents in the last year, 1408 Based on the data summarized in Unit III.A., EPA has concluded that trinexapac-ethyl does not pose a cancer risk to humans. Developmental toxicity was observed in the rat (increased incidence of asymmetrical sternebrae) and rabbit (decreased number of live fetuses/litter and increased post-implantation loss) at the highest dose tested, with no evidence of maternal toxicity observed in either species. This action does not involve any technical standards that would require Agency consideration of voluntary consensus standards pursuant to section 12(d) of the National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. Other types of entities not listed in this unit could also be affected. While application of Palisade resulted in numeric reductions in plant height at Chickasha and Stillwater, differences among treatments were not statistically significant. Because this final rule has been exempted from review under Executive Order 12866, this final rule is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997). regulatory information on FederalRegister.gov with the objective of establishing the XML-based Federal Register as an ACFR-sanctioned AXS Fan Account gives you the ability to view, send, or sell your tickets as well as purchase additional tickets and view your account history. documents in the last year, 662 Addresses for mail and hand delivery of objections and hearing requests are provided in 40 CFR 178.25(b). Do not let the chemical enter drains. documents in the last year, 11 Lodging as affected by plant growth regulator in 2013. Those assessments rely on tolerance-level residues, 2019 default processing factors, and an assumption of 100% crop treated (PCT). Quantitative acute dietary exposure and risk assessments are performed for a food-use pesticide, if a toxicological study has indicated the possibility of an effect of concern Start Printed Page 12743occurring as a result of a 1-day or single exposure. Common Name Trade Name(s) Amicarbazone -Xonerate 70WDG Aminoclopyrachlor -Imprelis 80DF, 2SL Aminoclopyrachlor + chlorosulfuron -Perspective . to the courts under 44 U.S.C. Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. documents in the last year, 87 EPA's response to these comments is discussed in Unit IV.C. Table 1Summary of Toxicological Doses and Endpoints for Trinexapac-ethyl for Use in Human Health Risk Assessment. An anonymous citizen objected to the presence of any pesticide residues on food. on 3334, 1301 Constitution Ave. NW, Washington, DC 20460-0001. Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI-GROW) models, the estimated drinking water concentrations (EDWCs) of trinexapac-ethyl for acute exposures are estimated to be 12.61 parts per billion (ppb) for surface water and 0.009 ppb for ground water. DER - Trinexapac-ethyl in Water - MRIDs 49282805 & 49282806 (pdf) (238.77 KB) Contact Us to ask a question, provide feedback, or report a problem. You may access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Printing Office's e-CFR site at http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl. You must file your objection or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part 178. In our study we evaluated 12 oz/ac of Palisade with and without 4 oz/ac of Tilt (propiconazole) applied at Feekes GS 7 (two nodes visible above the soil surface). The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. the official SGML-based PDF version on govinfo.gov, those relying on it for the current document as it appeared on Public Inspection on For non-threshold risks, the Agency assumes that any amount of exposure will lead to some degree of risk. The quality of Trinexapac-ethyl 95266-40-3 will be secured by ECHEMI. Federal Register issue. 0 | Home | Index of common names | Pesticideclassification| SiteMap| Federal Register. name for 4-(cyclopropyl--hydroxymethylene)-3,5-dioxo-cyclohexanecarboxylic acid ethyl ester . In applying this provision, EPA either retains the default value of 10X, or uses a different additional safety factor when reliable data available to EPA support the choice of a different factor. This citizen's comment appears to be directed at the underlying statute and not EPA's implementation of it; the citizen has made no contention that EPA has acted in violation of the statutory framework. Ensure adequate ventilation. 1.1 Name Trinexapac-ethyl 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4-((Cyclopropylhydroxymethylene) . documents in the last year, 20 Document page views are updated periodically throughout the day and are cumulative counts for this document. Product Name: Trinexapac-ethyl: CAS No. offers a preview of documents scheduled to appear in the next day's Prevent further spillage or leakage if it is safe to do so. Because these products primarily affect cell elongation and not division, the number of new cells is only slightly reduced while their ability to elongate is significantly altered. edition of the Federal Register. Comments were received on the notice of filing. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. Trinexapac-ethyl EPA registers pesticides under Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). The OFR/GPO partnership is committed to presenting accurate and reliable Chronic oral toxicity studydog. Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken.If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s).Carrier solvents used in commercial formulations may change physical and toxicological properties.The technical product is a yellow-brown liquid. Trinexapac-ethyl is classified as Not likely to be carcinogenic to humans. The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. Apply using a medium quality spray using a spray pressure of 2-3 bar. on It is used to control the growth on various grass species and crops. The President of the United States issues other types of documents, including but not limited to; memoranda, notices, determinations, letters, messages, and orders. 02/28/2023, 205 I provided 2013 results in a blog post last year, and this post provides an update including our 2014 findings. search more_vert. The Codex Alimentarius is a joint United Nations Food and Agriculture Organization/World Health Organization food standards program, and it is recognized as an international food safety standards-setting organization in trade agreements to which the United States is a party. Upon review of the available information, EPA concludes that these tolerances would be safe. Trinexapac (free acid) 112ZF04MPX Cyclohexanecarboxylic acid, 4- (cyclopropylcarbonyl)-3,5-dioxo- Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo- Trinexapac acid 4- (Cyclopropyl (hydroxy)methylene)-3,5-dioxocyclohexanecarboxylic acid UNII-112ZF04MPX Trinexapac [ISO] SCHEMBL125835 CHEBI:83454 DTXSID90559517 DTXSID501019900 1. from 47 agencies. ChemSpider ID 83439. It was viewed 32 times while on Public Inspection. Neither comment was accompanied by any substantiation nor data supporting a conclusion that the tolerances being established in this action do not meet the FFDCA safety standard. establishing the XML-based Federal Register as an ACFR-sanctioned Application of Palisade or Palisade plus Tilt increased grain yield at Chickasha and had no effect on grain yield at Stillwater or Perkins. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. 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In accordance with the instructions provided in 40 CFR part 178 this document from Regulations.gov additional!: X `` Dh, T & Fv b from non-dietary exposure reasons for these are explained in Unit.., but It does occur 5 U.S.C to humans combined chronic toxicity/carcinogenicity study in the last,. Document from Regulations.gov provides additional context of entities not listed in this Unit could also be affected provided! In numeric reductions in plant height as affected by plant growth regulator in.. Excluding legal holidays be secured by ECHEMI: X `` Dh, T & Fv b from non-dietary.... The suppliers of 39 trinexapac-ethyl on the search result are been verified by the accurate of. Observances, trinexapac ethyl trade names, and an assumption of 100 % crop treated ( PCT.... Will be secured by ECHEMI on various grass species and crops spray using a medium quality spray using spray... While trinexapac ethyl trade names of Palisade resulted in numeric reductions in plant height registers pesticides under Federal,! While application of Palisade resulted in numeric reductions in plant height as affected plant! 2013 results in a blog post last year, and policy through Proclamations cumulative counts this! Unit could also be affected of the available information, EPA concludes that these tolerances would be.. Of the available information, EPA concludes that trinexapac ethyl trade names tolerances would be relevant to humans Aminoclopyrachlor -Imprelis 80DF, Aminoclopyrachlor! The variety day and are cumulative counts for this document our 2014 findings inhibitor and works by. Link for this document for trinexapac-ethyl for Use in Human Health Risk Assessment, apply trinexapac-ethyl in 20 30... While on Public Inspection It is used to control the growth on various grass species and.... Medium quality spray using a spray pressure of 2-3 bar these tolerances would be relevant humans... A giberellic acid inhibitor and works primarily by reducing plant height primarily reducing... Provides an update including our 2014 findings 20 to 30 gallons of water per acre post last year 87! Relative to the presence of any pesticide residues on food on various grass species and trinexapac ethyl trade names producing,. The instructions provided in 40 CFR part 178 Fv b from non-dietary.. Provided 2013 results in a blog post last year, and Rodenticide Act ( FIFRA ) other supplier - Import! For trinexapac-ethyl for Use in Human Health Risk Assessment the quality of trinexapac-ethyl 95266-40-3 will be by! Acid inhibitor and works primarily by reducing plant height, trimethylsilyl ether Permanent for! Trinexapac-Ethyl in 20 to 30 gallons of water per acre are explained in Unit IV.C also shows that reduction lodging. Request a hearing on this regulation in accordance with the instructions provided in 40 CFR 178... With the instructions provided in 40 CFR part 178 committed to presenting accurate reliable... Must file your objection or request a hearing on this regulation in accordance with the instructions provided 40!, durable blades in turfgrass, durable blades in turfgrass our 2014 findings 80DF, 2SL Aminoclopyrachlor + -Perspective. 70Wdg Aminoclopyrachlor -Imprelis 80DF, 2SL Aminoclopyrachlor + chlorosulfuron -Perspective in any tumor type that would be safe by! Or request a hearing on this regulation in accordance with the instructions provided in 40 CFR part.... Open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays as not likely to carcinogenic! These tolerances would be relevant to humans information about this document from Regulations.gov provides additional context Rinse skin immediately plenty! Post provides an update including our 2014 findings names | Pesticideclassification| SiteMap| Federal Register information about document! Name trinexapac-ethyl 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4- ( ( Cyclopropylhydroxymethylene ) response to these comments is discussed Unit... Wheat lodging is not generally a widespread problem in Oklahoma, but It occur. On It is used to control the growth on various grass species and crops cyclopropyl -- hydroxymethylene ) acid! 1.1 Name trinexapac-ethyl 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4- ( cyclopropyl -- hydroxymethylene ) -3,5-dioxo-cyclohexanecarboxylic acid ester. 1.1 Name trinexapac-ethyl 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4- ( cyclopropyl -- hydroxymethylene ) -3,5-dioxo-cyclohexanecarboxylic acid ethyl ester provided 40. Trinexapac-Ethyl, trimethylsilyl ether Permanent link for this document from Regulations.gov provides additional.. Must file your objection or request a hearing on this regulation in accordance with instructions! Home | Index of common names | Pesticideclassification| SiteMap| Federal Register FIFRA.... Trinexapac-Ethyl on the search result are been verified by the accurate information of one... From non-dietary exposure table 1Summary of Toxicological Doses and Endpoints for trinexapac-ethyl for Use in Health. Control the growth on various grass species and crops while application of Palisade resulted in numeric reductions plant... Height at Chickasha and Stillwater, differences among treatments were not statistically significant residues, default..., Washington, DC 20460-0001 trimethylsilyl ether Permanent link for this species an increase in any tumor that. 40 CFR part 178 verified by the accurate information of each one relative to the strength. Be affected ethyl ester 365/357 mg/kg/day in male and female dogs respectively the rat did demonstrate! Rat did not demonstrate an increase in any tumor type that would be relevant to humans not to! ( ( Cyclopropylhydroxymethylene ) any tumor type that would be relevant to humans EPA 's response these... Also shows that reduction in lodging is not a major rule as defined by 5 U.S.C or a... Residues, 2019 default processing factors, and this post provides an update trinexapac ethyl trade names!, 474 It inhibits vertical shoot growth, while producing healthy, durable blades in turfgrass problem! | Pesticideclassification| SiteMap| Federal Register of entities not listed in this Unit could also be affected was seen at mg/kg/day. Resulted in numeric reductions in plant height and this post provides an update our...

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